Panagiota (Nota) Klentrou, PhD, FCSEP

Professor, Kinesiology

Dr. Klentrou is an  exercise  physiologist  who  uses applied and basic science approaches to study  human performance and health implications of sport training in children and youth.  Supported by   NSERC, CIHR and  various  sports agencies,  her current research  is trying to identify the cellular mechanisms   that explain how exercise and diet affect bone development and lifelong bone health.  With  >120 publications Dr.  Klentrou is a leader in her field , and  involved  with  many  health and  sports organizations including  Osteoporosis Canada, and the International Gymnastics Federation.   

  • Health, Training and Performance in Youth  
  • Bone Physiology  
  • Integrated inflammatory and bone responses to exercise and  nutritio n  
  • The role of  adiposity and  diet   in  skeletal growth ,  development  and adaptation  
  • Sclerostin and tissue cross talk  


    • Former  Chair and Fellow of the  Canadian Society of Exercise Physiology (CSEP)
    • Member, Scientific Advisory Board, Osteoporosis Canada
    • Scientific Expert, Fédération International de Gymnastique (FIG)
    • Results Manager of all Gymnastics Events, 2015 Toronto PanAm Games and Athens 2004 Summer Olympic Games
    • Member, North American Society of Pediatric Exercise Medicine (NASPEM)
    • Member, American College of Sports Medicine (ACSM)
  1. Klentrou P , and   Kouvelioti  R , Biochemistry of Exercise Training: Effects on Bone . I PM  Tiidus , REK MacPherson, PJ LeBlanc ,  AR  Josse   ( Eds ) . Routledge Handbook on Biochemistry of Exercise , Routledge/Taylor and Francis Publishers, New York USA & Oxon UK, (ISBN 978-0-367-22383-0) pp. 513-531, 2021 .  
  2. Kurgan N, McKee K, Calleja M,  Josse  AR, and Klentrou P. Cytokines, Adipokines and Bone Markers at Rest and in Response to Plyometric Exercise in Obese vs Normal Weight Adolescent Females.  Frontiers Endocrinology (Obesity) 11 December 2020. [] .  
  3. Sanderson M, McKinlay BJ,  Theocharidis  A,  Kouvelioti  R, Falk B, and Klentrou P. Changes in inflammatory cytokines and irisin in response to high-intensity swimming in adolescent and adult male swimmers.  Sports , 8(12): 157, 2020. [].  
  4. McKinlay B, Theocharidis A, Adebero T, Kurgan N, Fajardo VA, Roy BD, Josse AR, Logan- Sprenger H, Falk B, and Klentrou P*. Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers. Int. J. Environ. Res. Public Health, 17(21): 1-12, 2020. [].
  5. Nelson K,  Kouvelioti  R,  Theocharidis  A, Falk B,  Tiidus  P, and Klentrou P. Effects of plyometric exercise on Wnt signaling-related osteokines and bone turnover markers in pre and postmenopausal women.  BioMed Res. Int , vol. 2020, Article ID 7917309, 10 pages, 2020.  [].  
  6. Calleja M, Caetano  Feitoza  N, Falk B, Klentrou P, Ward WE, Sullivan P, and  Josse  AR. Increased dairy product consumption as part of a weight management program improves body composition in adolescent females with overweight and obesity – A Randomized Controlled Trial.  Pediatric   Obesity , June 2020. [ https:// doi: 10.1111/ijpo.12690].  
  7. Josse  AR,  Kouvelioti  R,  Ludwa  IA, Calleja M, Falk B, Ward WE, and Klentrou P.   Dairy product intake decreases bone resorption following a 12-week diet and exercise intervention in overweight and obese adolescent girls.  Ped. Res. , 88: 910-916, 2020. []  
  8. Woloschuk  A, Hodges GJ,  Massarotto  RJ, Klentrou P, and Falk B. The skin blood flow response to exercise in boys and men and the role of nitric oxide.  Eur. J. Appl. Physiol. 120:753-762, 2020 [].  
  9. Theocharidis  A, McKinlay B,  Vlachopoulos  D,  Josse  AR, Falk B, and Klentrou P.  Effects of post exercise protein supplementation  on bone turnover in adolescent swimmers.  J. Int. Soc. Sports  Nutr . 17:   20, 2020. [ ]  
  10. Adebero  T, McKinlay BJ,  Theocharidis  A, Root Z,  Josse  A, Klentrou P, and Falk B. Salivary and serum concentrations of cortisol and testosterone at rest and in response to
    intense exercise in boys versus men.  Ped.  Exerc . Sci. 32:65-72, 2020. [doi:10.1123/pes.2019-0091].   
  11. Hodges GJ, Klentrou P, Cheung SS, and Falk B. Comparison of laser speckle contrast imaging and laser-Doppler  fluxmetry  in boys and men.  Microvascular Res. , 128:103927, March 2020. []  
  12. Kouvelioti  R, Kurgan N, Falk B, Ward WE,  Josse  A, and Klentrou P. Cytokine and sclerostin response to high intensity interval running versus cycling.  Med. Sci.  Sports  Exerc ., 51(12):2458-2464, 2019. [ DOI:  10.1249/mss.0000000000002076 ].   
  13. Hodges GJ, Mallette MM, Rigby A, Klentrou P, Cheung SS, and Falk B. Comparison of different wheelchair seating on thermoregulation and perceptual responses in thermoneutral and hot conditions in children . J. Tissue Viability , 28:144-151, 2019. []  
  14. Thomas AM, Beaudry KM,  Gammage  K, Klentrou P, and  Josse  AR. Physical activity, sport participation and perceived barriers to engagement in first year university students.  J. Physical Activity Health , 16(6): 437-446, 2019.  
  15. Kouvelioti  R, LeBlanc P, Falk B, Ward WE,  Josse  AR, and Klentrou *. Effects of high-intensity interval running versus cycling on sclerostin, and markers of bone turnover and oxidative stress in young men.  Calcified Tissue Int. , 104(6): 582-590, 2019. []  
  16. Kurgan N,  Noaman  N, Pergande MR, Cologna SM,  Coorssen  JR,   and Klentrou P.  Changes to the human  proteom  in response to high intensity interval exercise: a sequential top-down proteomic analysis.  Frontiers Physiol. , 02 April 2019. [  
  17. Kurgan N, Bott KN,  Helmeczi  WE, Roy BD, Brindle ID, Klentrou P, and Fajardo VA. Low dose lithium supplementation activates Wnt/ β -catenin  signalling  and increases bone OPG/RANKL ratio in mice.  Biochem Biophys . Res. Comm. (BBRC) , 511(2): 394-397, 2019. []  
  18. Kouvelioti  R, Kurgan N, Falk B, Ward WE,  Josse  AR, and Klentrou P. Response of sclerostin and bone turnover markers to high-intensity interval exercise in young women: does impact matter?  BioMed Research International , vol. 2018, Article ID 4864952, 2018. []  
  19. Klentrou P,  Angrish  K,  Awadia  N, Kurgan N,  Kouvelioti  R, and Falk B.  Wnt signaling related osteokines at rest and following plyometric exercise in boys and girls.  Ped.  Exrc . Sci ., 30: 457-465, 2018 .  
  20. Falk B, and Klentrou P. Elevation in sclerostin after exercise: is it affected by age and sex? Letter to the editor;  Endocrine , 102(3):380-381, 2018.  
  21. Hodges GJ,  Kiviniemi  AM, Mallette MM, Klentrou P, Falk F, and Cheung SS. Effect of passive heat exposure on cardiac autonomic function in healthy children.  Eur. J. Appl. Physiol. , 118:2233-2240, 2018.  
  22. Kurgan N, Logan-Sprenger H, Falk B, and Klentrou P. Training,  inflammation  and bone markers in elite female rowers during an Olympic year.  Med. Sci. Sports  Exerc ., 50(9): 1810-1817, 2018.  
  23. Dekker J, Nelson K, Kurgan N, Falk F,  Josse  A, and Klentrou P. Wnt Signaling-related osteokines and transforming growth factors before and after a single bout of plyometric exercise in child and adolescent females.  Ped.  Exerc . Sci. , 29: 504-512, 2017.  
  24. Kouvelioti  R,  Josse  AR, Klentrou P.  The effects of dairy consumption with and without exercise on body composition and bone in youth: a systematic review.  Curr . Dev.  Nutr .  Cdn.117.001214; July 2017 [ doi :] .  
  25. Allison D, Gabriel DA, Klentrou P,  Josse  AR, and  Ditor  DS. The influence of chronic inflammation on peripheral motor nerve conduction following spinal cord injury: A randomized clinical trial.   Topics Spinal Cord Injury Rehab. , 23(4): 377-385, 2017.  
  26. Wilkinson K,  Vlachopoulos  D, Klentrou P,  Ubago-Guisado  E, de  Moraes  AC, Barker AR, Craig A Williams CA, Moreno LA, and  Gracia -Marco L.  Soft tissues, bone mineral density and geometry in active adolescent boys: The PRO-BONE study.  Eur. J. Appl. Physiol. , 117:833–842, 2017.  
  27. Ludwa  IA, Falk B, Ward WE,  Gammage  KL, and Klentrou P. Mechanical, biochemical and dietary determinants of the functional model of bone development in children.  Appl. Physiol.  Nutr . Metab . 42: 780–787, 2017.   
  28. Kurgan N,  Tsakiridis   E,  Kouvelioti  R, Moore J, Klentrou P, and  Tsiani  E. Inhibition of human lung cancer cell proliferation and survival by post-exercise serum is associated with inhibition of Akt, mTOR, p70 S6K and Erk1/2.  Cancers , 9: 46, 2017 [doi:10.3390/cancers9050046].  
  29. Klentrou P. Influence of exercise and training during critical stages of bone growth and development.  Ped.  Exerc . Sci. , 28(2): 178-186, 2016. (Invited review)  
  30. Allison D,  Josse  AR, Gabriel DA, Klentrou P, and  Ditor  DS. Targeting inflammation to influence cognitive function following spinal cord injury: A Randomized Clinical Trial.  Spinal Cord , 21 June 2016. [ doi:10.1038/sc.2016.96].  
  31. Moore J,  Megaly  M, MacNeil AJ, Klentrou P, and  Tsiani   E. Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells.  Biomedicine & Pharmacotherapy 83:725-732 , 2016.   
  32. Klentrou P,  Giannopoulou  A, McKinlay B, Wallace P, Muir C, Falk B, and Mack D. Salivary cortisol and testosterone responses to resistance and plyometric exercise in  12-14 year old  boys.  Appl. Physiol.  Nutr Metab . , 41: 1-5, 2016.  
  33. Lamarche L,  Gammage  KL, Kerr G, Faulkner G, and Klentrou P .  Psychological and cortisol responses to a body image threat: addressing the challenges of actual threat exposure in an ethical manner.  SAGE Open ,  1-9, April-June 2016. [ doi : 10.1177/2158244016642378].  
  34. Falk B, Haddad F, Klentrou P, Ward W, Kish K,  Mezil   M, and Radom- Aizik  S.  Differential sclerostin and parathyroid hormone response to exercise in boys and men.  Osteoporosis Int ., 27(3): 1245-1249 , 2016 .  
  35. Chirico C, Liu   L, Klentrou   P, Shoemaker   JK, and O’Leary DD. Examining the effects of sex and pubertal maturation on cardiovagal baroreflex sensitivity in children and adolescents.  J. Pediatrics , 167(5): 1067–1073, 2015.  
  36. Kish K,  Mezil  Y, Ward WE, Klentrou P, and Falk B. Effects of a single session of plyometric exercise on markers of bone turnover in boys and men.  Eur. J. Applied Physiol.,  115: 2115–2124, 2015.  
  37. Cook O, Frost G,  Twose  D,  Wallman  L, Falk B, Galea V, Adkin A, and Klentrou P CAN-flip: a pilot gymnastics program for children with cerebral palsy.  Adapted Physical Activity Quarterly 32: 349-370, 2015 .  
  38. Akseer  N, Kish K, Rigby WA, Greenway M, Klentrou P, Wilson PM, and Falk B. Does bracing affect bone health in women with adolescent idiopathic scoliosis?  Scoliosis , 10:5, 2015. [ doi : 10.1186/s13013-015-0031-1].  
  39. Chirico D, Wade T, Cairney J, Klentrou P, and O’Leary D. Evidence of a hyperkinetic state in children with elevated blood pressure.  Ann. Human Biol. , 42(3): 246-252, 2015.   
  40. Mezil  Y, Allison D, Kish K,  Ditor  D,  Tsiani  L, Ward W, and Klentrou P .   Response of bone turnover markers and cytokines to high-intensity low-impact exercise.  Med. Sci. Sports  Exerc .,  47: 1495-1502, 2015.    
  • Human Systems Anatomy and Physiology
  • Exercise Physiology
  • Growth and Development
  • Fellow, Canadian Society for Exercise Physiology (CSEP), 2020  
  • Marilyn Rose Graduate Leadership Award, 2017
  • Graduate students’ nominee for the Graduate Mentorship Award, 2013
  • Undergraduate Students’ nominee, TVO’s Best Lecturer competition, 2010
  • Chancellor’s Chair for Research Excellence Award, 全球电竞直播 , 2009 Current Research Funding:
  • Award for Distinguished Research & Creative Activity, 全球电竞直播 , 2006